SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent.

@article{Helmke1998SRCBT,
  title={SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent.},
  author={Steve M. Helmke and Kerstin Lohse and Keith Mikule and Malcolm R. Wood and Karl H. Pfenninger},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 16)},
  pages={2465-75}
}
The interaction of the non-receptor tyrosine kinase, Src, with the cytoskeleton of adhesion sites was studied in nerve growth cones isolated from fetal rat brain. Of particular interest was the role of protein tyrosine phosphatases in the regulation of Src-cytoskeleton binding. Growth cones were found to contain a high level of protein tryrosine phosphatase activity, most of it membrane-associated and forming large, multimeric and wheat germ agglutinin-binding complexes. The receptor tyrosine… CONTINUE READING
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Rapid activation of the T - cell tyrosine protein kinase pp 561 ck by the CD 45 phosphotyros phosphatase

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