SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator

@inproceedings{Ma2011SRC3HA,
  title={SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator},
  author={Gang Ma and Yu Hu Ren and Ke Wang and Jianjun He},
  booktitle={International journal of biological sciences},
  year={2011}
}
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation of hormone-dependent cancers. However, increasing clinical evidence shows that dysregulation of SRC-3… CONTINUE READING

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