SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization.

@article{Bignon1999SR146131AN,
  title={SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization.},
  author={E Bignon and Richard Alonso and Mich{\`e}le Arnone and Robert Boigegrain and Roger Brodin and Christiane Gueudet and M. de Heaulme and Peter Keane and Miriam Landi and Jerome Molimard and D Olliero and Martine Poncelet and E Seban and J. Simiand and Philippe Soubri{\'e} and Matthew Pascal and Jean Pierre Maffrand and G{\'e}rard Le Fur},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 2},
  pages={752-61}
}
SR146131 is a potent and selective agonist at cholecystokinin subtype 1 (CCK1) receptors in vitro. The present study evaluates the activity of the compound in vivo. SR146131 completely inhibited gastric and gallbladder emptying in mice (ED50 of 66 and 2.7 micrograms/kg p.o., respectively). SR146131 dose dependently reduced food intake in fasted rats (from 0.1 mg/kg p.o.), in nonfasted rats in which food intake had been highly stimulated by the administration of neuropeptide Y (1-36) (from 0.3… CONTINUE READING