SR141716A is an inverse agonist at the human cannabinoid CB1 receptor.

  title={SR141716A is an inverse agonist at the human cannabinoid CB1 receptor.},
  author={Robin Landsman and Thomas H Burkey and Paul F. Consroe and W. R{\"o}ske and Henry I. Yamamura},
  journal={European journal of pharmacology},
  volume={334 1},
The effects of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4- benzoxazin-yl]-(1-napthalenyl)methanone mesylate (WIN 55,212-2) and N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazo le-carboxamide (SR141716A) on guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to membranes isolated from human cannabinoid CB1 receptor-transfected Chinese hamster ovary (CHO) cells were examined. WIN 55,212-2 stimulated [35S]GTPgammaS binding 76.3… CONTINUE READING

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