SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

@article{RinaldiCarmona1994SR141716AAP,
  title={SR141716A, a potent and selective antagonist of the brain cannabinoid receptor},
  author={Murielle Rinaldi-Carmona and Francis Barth and Michel H{\'e}aulme and David Shire and Bernard Calandra and Christian Congy and Serge Martinez and Jean Maruani and Gervais N{\'e}liat and Daniel Caput and Pascual Ferrara and Philippe Soubrié and Jean Claude Breliere and Gérard Le Fur},
  journal={FEBS Letters},
  year={1994},
  volume={350}
}
The therapeutic applications of cannabinoid agonists and antagonists
TLDR
Antagonists have now also been described for both receptor subtypes, which are involved in analgesia, cognition, memory, locomotor activity, control of appetite and vomiting, regulation of intestinal, bronchial and uterine contraction, and control of intra-ocular pressure.
Pharmacology of cannabinoid CB1 and CB2 receptors.
  • R. Pertwee
  • Biology, Medicine
    Pharmacology & therapeutics
  • 1997
Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors
TLDR
These results suggest for the first time that endogenous cannabinoid systems may modulate the appetitive value of sucrose and ethanol, perhaps by affecting the activity of brain reward systems.
New cannabinoid receptor antagonists as pharmacological tool.
SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.
TLDR
It is expected that SR 144528 will provide a powerful tool to investigate the in vivo functions of the cannabinoid system in the immune response.
SR147778, A NEW POTENT AND SELECTIVE ANTAGONIST OF THE CB1 CANNABINOID RECEPTOR. BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION
TLDR
SR147778 is introduced as a highly potent, selective and orally active antagonist for the CB1 receptor, which is able to reduce both ethanol or sucrose consumption in mice and rats and food intake in fasted and non-deprived rats.
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