SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice

  title={SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/$\mu$-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice},
  author={Taline V. Khroyan and Nurulain T. Zaveri and Willma E. Polgar and Juan Ordu{\~n}a and Cris M. Olsen and Faming Jiang and Lawrence Toll},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={934 - 943}
  • T. Khroyan, N. Zaveri, L. Toll
  • Published 1 February 2007
  • Biology, Psychology
  • Journal of Pharmacology and Experimental Therapeutics
We identified a novel nociceptin/orphanin FQ (NOP)/μ-opioid receptor agonist, SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], with high binding affinity and partial agonist activity at both receptors. It was hypothesized that SR 16435 would produce antinociception and yet, unlike morphine, would have diminished rewarding properties and tolerance development. Antinociception was assessed in mice using the tail-flick assay, whereas behavioral and rewarding effects were… 

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