SR/ER-mitochondrial local communication: calcium and ROS.

  title={SR/ER-mitochondrial local communication: calcium and ROS.},
  author={Gy{\"o}rgy Csord{\'a}s and Gy{\"o}rgy Hajn{\'o}czky},
  journal={Biochimica et biophysica acta},
  volume={1787 11},
Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support signal transduction and biosynthetic pathways and affect organellar distribution. Recently, these junctions have received attention because of their pivotal role in mediating calcium signal propagation to the mitochondria, which is important for both ATP production and mitochondrial cell death. Many of the SR/ER-mitochondrial calcium transporters and signaling proteins are sensitive to redox regulation and… CONTINUE READING
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