SQUID-based instrumentation for ultralow-field MRI

  title={SQUID-based instrumentation for ultralow-field MRI},
  author={Vadim Zotev and Andrei Matlashov and Petr L Volegov and Algis V Urbaitis and Michelle A. Espy and Robert H. Kraus},
  journal={Superconductor Science and Technology},
Magnetic resonance imaging at ultralow fields (ULF MRI) is a promising new imaging method that uses SQUID sensors to measure the spatially encoded precession of pre-polarized nuclear spin populations at a microtesla-range measurement field. In this work, a seven-channel SQUID system designed for simultaneous 3D ULF MRI and magnetoencephalography (MEG) is described. The system includes seven second-order SQUID gradiometers characterized by magnetic field resolutions of 1.2–2.8 fT Hz−1/2. It is… 
Toward High Resolution Images With SQUID-Based Ultra-Low Field Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is the state-of-the-art clinical method for imaging soft-tissue anatomy. Because signal scales with the applied magnetic field, the overwhelming trend in MRI has been
Low-field MRI measurements using a tuned HTS SQUID as detector and permanent magnet pre-polarization field
In order to improve the signal-to-noise ratio (SNR) of low-field (LF) magnetic resonance imaging (MRI) measurements with a tuned high-Tc rf superconducting quantum interference device (SQUID) as a
Applications of Ultra-Low Field Magnetic Resonance for Imaging and Materials Studies
Recently it has become both possible and practical to perform MR at magnetic fields from muT to mT, the so-called ultra-low field (ULF) regime. SQUID sensor technology allows for ultra-sensitive
Ultra-low field Magnetic Resonance Imaging using high-Tc SQUIDs
A measurement system for ultra-low field Magnetic Resonance Imaging (ulf-MRI) has been built and programmed and a few proof-of- principle 2D images of water phantoms have been acquired at 89.3 μT
Fast Room Temperature Very Low Field-Magnetic Resonance Imaging System Compatible with MagnetoEncephaloGraphy Environment
A room-temperature, MEG-compatible very-low field (VLF)-MRI device working in the range of several hundred kHz without sample pre-polarization is presented and reduced imaging time is achieved based on preliminary results using phantoms and ex-vivo rabbits heads.
An advanced phantom study assessing the feasibility of neuronal current imaging by ultra-low-field NMR.
Low Field MRI Detection With Tuned HTS SQUID Magnetometer
We set up a low field (LF) magnetic resonance imaging (MRI) system with a tuned high-Tc (HTS) superconducting quantum interference device (SQUID) consisting of a SQUID magnetometer and a
Sub-millimetric ultra-low-field MRI detected in situ by a dressed atomic magnetometer
Magnetic resonance imaging (MRI) is universally acknowledged as an excellent tool to extract detailed spatial information with minimally invasive measurements. Efforts toward ultra-low-field (ULF)


SQUID-detected in vivo MRI at microtesla magnetic fields
We use a low transition temperature (T/sub c/) Super-conducting Quantum Interference Device (SQUID) to perform in vivo magnetic resonance imaging (MRI) at magnetic fields around 100 microtesla,
Multi-Channel SQUID System for MEG and Ultra-Low-Field MRI
A seven-channel system capable of performing both magnetoencephalography (MEG) and ultra-low-field magnetic resonance imaging (ULF MRI) is described. The system consists of seven second-order SQUID
Simultaneous magnetoencephalography and SQUID detected nuclear MR in microtesla magnetic fields
These measurements demonstrate, for the first time, the feasibility of simultaneous MRI and MEG, and enable direct measurement of neuronal activity with high temporal resolution via MEG.
Microtesla MRI with a superconducting quantum interference device.
It is shown that prepolarization of the nuclear spins and detection with a superconducting quantum interference device (SQUID) yield a signal that is independent of B0, allowing acquisition of high-resolution MRIs in microtesla fields.
SQUID-based simultaneous detection of NMR and biomagnetic signals at ultra-low magnetic fields
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at ultra-low magnetic fields (ULF, fields of /spl sim//spl mu/T) have several advantages over their counterparts at higher
SQUID Systems Adapted to Record Nuclear Magnetism in Low Magnetic Fields
We modified two SQUID measurement systems, originally developed and optimized for biomagnetic applications, with the aim to employ them for observing the precession of nuclear magnetism in low fields
SQUID-Detected Magnetic Resonance Imaging in Microtesla Magnetic Fields
We describe studies of nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) of liquid samples at room temperature in microtesla magnetic fields. The nuclear spins are
On concomitant gradients in low-field MRI.
SQUID detected NMR in microtesla magnetic fields.