SPXX, a frequent sequence motif in gene regulatory proteins.

  title={SPXX, a frequent sequence motif in gene regulatory proteins.},
  author={Masao Suzuki},
  journal={Journal of molecular biology},
  volume={207 1},
A new DNA-binding unit, composed of four amino acid residues and common in gene regulatory proteins, is proposed. The occurrences of the sequences Ser-Pro-X-X (SPXX) and Thr-Pro-X-X (TPXX) in gene regulatory proteins are compared with those in general proteins. These sequences are found more frequently in gene regulatory proteins including homoeotic gene products, segmentation gene products, steroid hormone receptors and certain oncogene products, than they are in DNA-binding proteins that are… CONTINUE READING


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