SPR741, an Antibiotic Adjuvant, Potentiates the In Vitro and In Vivo Activity of Rifampin against Clinically Relevant Extensively Drug-Resistant Acinetobacter baumannii

@article{Zurawski2017SPR741AA,
  title={SPR741, an Antibiotic Adjuvant, Potentiates the In Vitro and In Vivo Activity of Rifampin against Clinically Relevant Extensively Drug-Resistant Acinetobacter baumannii},
  author={D. Zurawski and Alexandria A. Reinhart and Yonas A. Alamneh and M. Pucci and Y. Si and R. Abu-Taleb and Jonathan P. Shearer and Samandra T. Demons and S. Tyner and T. Lister},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2017},
  volume={61}
}
  • D. Zurawski, Alexandria A. Reinhart, +7 authors T. Lister
  • Published 2017
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT Acinetobacter baumannii is responsible for 10% of all nosocomial infections and has >50% mortality rates when causing ventilator-associated pneumonia. In this proof-of-concept study, we evaluated SPR741, an antibiotic adjuvant that permeabilizes the Gram-negative membrane, in combination with rifampin against AB5075, an extensively drug-resistant (XDR) A. baumannii strain. In standard in vitro assays and in a murine pulmonary model, we found that this drug combination can significantly… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741
    • 50
    • PDF
    An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria.
    • 24
    • PDF