SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy: predicting the severity of Duchenne muscular dystrophy: implications for treatment.

@article{Kyriakides2011SPP1GI,
  title={SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy: predicting the severity of Duchenne muscular dystrophy: implications for treatment.},
  author={Theodoros Kyriakides and Elena Pegoraro and Eric P. Hoffman and Luisa Piva and Stefano Cagnin and Giuseppina Lanfranchi and Robert Griggs and Stanley F. Nelson},
  journal={Neurology},
  year={2011},
  volume={77 20},
  pages={1858; author reply 1858-9}
}
PREDICTING THE SEVERITY OF DUCHENNE MUSCULAR DYSTROPHY: IMPLICATIONS FOR TREATMENT To the Editor: Variability in disease severity in Duchenne muscular dystrophy (DMD) is considered a biological phenomenon, possibly due to genetic or epigenetic mechanisms. It was exciting to read the article by Pegoraro et al.1 describing the discovery of osteopontin as a possible modifier gene. As discussed in the accompanying editorial by Drs. Nelson and Griggs,2 utrophin and myostatin are 2 other proteins… CONTINUE READING

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