SPP-3, a saposin-like protein of Caenorhabditis elegans, displays antimicrobial and pore-forming activity and is located in the intestine and in one head neuron.

@article{Hoeckendorf2012SPP3AS,
  title={SPP-3, a saposin-like protein of Caenorhabditis elegans, displays antimicrobial and pore-forming activity and is located in the intestine and in one head neuron.},
  author={Aylin Hoeckendorf and Matthias Leippe},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={38 1},
  pages={181-6}
}
Caenopores belong to the saposin-like protein superfamily in Caenorhabditis elegans with 33 putative antimicrobial and pore-forming proteins. In this study, we analysed one selected member of this multifarious protein family, namely SPP-3, in detail, as its coding gene has been described to be inducible after bacterial challenge. The recombinant protein was antimicrobially active against a wide range of gram-negative and gram-positive bacteria and displayed membrane-permeabilizing and pH… CONTINUE READING