SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

@article{Jin2019SPOPTO,
  title={SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.},
  author={Xiaofeng Jin and Jiao Wang and Qian Qian Li and Hui Zhuang and Jianye Yang and Zihan Lin and Ting Lin and Zeheng Lv and Liliang Shen and Chunhong Yan and Jingfei Zheng and Jie Zhu and Zhaohui Gong and Chenji Wang and Kun Gao},
  journal={American journal of cancer research},
  year={2019},
  volume={9 12},
  pages={
          2797-2812
        }
}
  • X. Jin, J. Wang, +12 authors K. Gao
  • Published 2019
  • Chemistry, Medicine
  • American journal of cancer research
Dysregulation of the ubiquitin-proteasome pathway is closely associated with cancer initiation and progression. SPOP is an adapter protein of the CUL3-based E3 ubiquitin ligase complexes. Several whole genome/exome sequencing studies on endometrial cancers (ECs) revealed that the SPOP gene is frequently mutated. However, how SPOP mutations contribute to EC remains poorly understood. In this study, transcription factor ZBTB3 was identified as a proteolytic substrate for the SPOP-CUL3-RBX1 E3… Expand
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  • Biochemical and biophysical research communications
  • 2021
TLDR
This study shows that the germ line-specific factor DPPA2 was identified as a proteolytic substrate for the SPOP-CUL3-RBX1 E3 ubiquitin-ligase complex and contributes to the malignant transformation phenotypes of TGCT cells. Expand
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  • Nucleic acids research
  • 2021
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It is reported that upon DNA damage, SPOP is phosphorylated at Ser119 by the ATM serine/threonine kinase, which potentiates the binding of SPOP to homeodomain-interacting protein kinase 2 (HIPK2), resulting in a nondegradative ubiquitination of HIPK2. Expand
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  • Medicine
  • Cancer cell international
  • 2021
TLDR
It is demonstrated that dysregulation of the ROC1–SUFU–GLI2 axis plays an important role in bladder cancer progression and that targeting Roc1 expression is warranted in further investigations as a novel strategy for the future control of bladder cancer. Expand
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  • Oncology letters
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The structure and function of LZTR1 are described and recent advances in the current knowledge of the functions of LzTR1 in NS, glioblastoma, chronic myeloid leukemia, CML and schwannomatosis are discussed, providing insight into how LZ TR1 may be targeted for therapeutic purposes. Expand