SPOP mutations in prostate cancer across demographically diverse patient cohorts.

  title={SPOP mutations in prostate cancer across demographically diverse patient cohorts.},
  author={Mirjam Blattner and Daniel J Lee and Catherine O'Reilly and Kyung Ja Park and Theresa Macdonald and Francesca Khani and Kevin R. Turner and Ya-lin Chiu and Peter J. Wild and Igor Dolgalev and Adriana Heguy and Andrea Sboner and Sinan Ramazangolu and Haley Hieronymus and Charles L Sawyers and Ashutosh Tewari and Holger Moch and Ghil Suk Yoon and Yong Chul Known and Ove Andr{\'e}n and Katja Fall and Francecsa Demichelis and Juan Miguel Mosquera and Brian Robinson and Christopher E Barbieri and Mark A. Rubin},
  volume={16 1},
BACKGROUND Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown. OBJECTIVE To investigate SPOP mutations across diverse cohorts and validate a series of assays employing high-resolution melting (HRM) analysis and Sanger sequencing for mutational analysis of formalin-fixed paraffin-embedded material. DESIGN SETTING AND PARTICIPANTS 720… CONTINUE READING


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