SPONTANEOUS REMISSION OF MULTI-SYSTEM HISTIOCYTOSIS X

@article{Broadbent1984SPONTANEOUSRO,
  title={SPONTANEOUS REMISSION OF MULTI-SYSTEM HISTIOCYTOSIS X},
  author={Valerie Broadbent and E. Graham Davies and David Heaf and J. R. Pincott and Jon Pritchard and Roland J. Levinsky and Duncan Atherton and S. M. Tucker},
  journal={The Lancet},
  year={1984},
  volume={323},
  pages={253-254}
}
Two infants presented with biopsy-proven histiocytosis X affecting multiple sites. Since neither showed evidence of organ failure or of constitutional upset, no specific therapy was given. In each case there was long-lasting spontaneous regression of disease. Analysis of blood mononuclear cells revealed a raised T4:T8 (helper:suppressor T lymphocyte) ratio at diagnosis but a normal ratio during remission. These observations support the argument that multi-system histiocytosis X, even in infants… Expand
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