SPONTANEOUS LEG CRAMPS AND “RESTLESS LEGS” DUE TO DIABETOGENIC HYPERINSULINISM: OBSERVATIONS ON 131 PATIENTS *

@article{Roberts1965SPONTANEOUSLC,
  title={SPONTANEOUS LEG CRAMPS AND “RESTLESS LEGS” DUE TO DIABETOGENIC HYPERINSULINISM: OBSERVATIONS ON 131 PATIENTS *},
  author={H. J. Roberts},
  journal={Journal of the American Geriatrics Society},
  year={1965},
  volume={13}
}
  • H. J. Roberts
  • Published 1 July 1965
  • Medicine
  • Journal of the American Geriatrics Society
The cause and rational treatment of spontaneous leg cramps (S.L.C.) and the “restless legs” phenomenon (R.L.) remain controversial. Although many neurologic, vascular, vasomotor and neurovascular etiologies have been suggested, they remain unconvincing as primary underlying causes in the face of clinical experience. An incomplete listing of such disorders includes peripheral venous stasis, prolonged dependency of the limbs by sitting or standing, previous thrombophlebitis, engorgement of the… 
Leg cramps (systremma0 and "restless legs" syndrome. Response to vitamin E (tocopherol).
TLDR
Nearly all of the patients with leg cramps received prompt and gratifying relief from their symptoms while taking vitamin E in the form of d, alpha-tocopheryl acetate, 100 I.U. three times a day before meals.
THE ROLE OF DIABETOGENIC HYPERINSULINISM IN NOCTURNAL ANGINA PECTORIS, WITH SPECIAL REFERENCE TO THE ETIOLOGY OF ISCHEMIC HEART DISEASE *
  • H. J. Roberts
  • Medicine
    Journal of the American Geriatrics Society
  • 1967
TLDR
The writer has been led to the premise that the underlying process most frequently triggering both nocturnal angina and the dream-arousal state is the progressive hypoglycemia caused by diabetogenic (L‘functional”) hyperinsulinism (D.H.)-or more accurately, myocardial and cerebral glucopenia-to which most of these patients are subject.
MOTOR MANIFESTATIONS IN MOLIMINA CRURUM NOCTURNA (INCLUDING “RESTLESS LEGS”)
  • R. Brenning
  • Medicine
    Journal of the American Geriatrics Society
  • 1971
TLDR
The author gives reasons why most nocturnal leg cramps can be classified as a symptom of MCN from a pathogenetic point of view, even if central‐nervous‐system impulses and preparation for muscular contraction are involved.
DELAYED THROMBOPHLEBITIS AND SYSTEMIC COMPLICATIONS AFTER VASECTOMY: POSSIBLE ROLE OF DIABETOGENIC HYPEREVSULINISM*
TLDR
Some serious disorders have been noted after vasectomy and the purported innocuousness of mass vasectomy programs in a famine-threatened country such as India may be non-indicative for the affluent nations.
MIGRAINE AND RELATED VASCULAR HEADACHES DUE TO DIABETOGENIC HYPERINSULINISM
TLDR
It has been apparent to many experienced clinicians that the primary cause for most vascular headaches cannot be convincingly ascribed to some vague allergy, deep-seated emotional disturbance, or local disorder involving the eyes and sinuses.
DELAYED THROMBOPHLEBITIS AND SYSTEMIC COMPLICATIONS AFTER VASECTOMY: POSSIBLE ROLE OF DIABETOGENIC HYPEREVSULINISM *
  • H. J. Roberts
  • Medicine
    Journal of the American Geriatrics Society
  • 1968
TLDR
The development of unexplained thrombophlebitis and puzzling systemic disorders within one to several years after elective vasectomy is reported, including induced hormonal imbalances, autosensitization to testicular nucleoproteins, and altered blood coagulation in the hyperinsulinized‐diabetic state.
Leg Cramps in Children
TLDR
Symptomatic treatment consists of stretching the affected calf muscle by forcible dorsiflexion of the foot.
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC HYPER‐INSULINISM IN THE AMERICAN NEGRO: IMPORTANT CLINICAL, SOCIAL AND PUBLIC HEALTH ASPECTS
  • H. J. Roberts
  • Medicine
    Journal of the American Geriatrics Society
  • 1965
The present era confronts those who are engaged in the biological sciences with the urgent and awesome responsibility of precisely clarifying legitimate racial variations for the purpose of promoting
AN INQUIRY INTO THE PATHOGENESIS, RATIONAL TREATMENT AND PREVENTION OF MULTIPLE SCLEROSIS, WITH EMPHASIS UPON THE COMBINED ROLE OF DIABETOGENIC HYPER‐INSULINISM AND RECURRENT EDEMA *
  • H. J. Roberts
  • Medicine
    Journal of the American Geriatrics Society
  • 1966
“In reality, it is not the pomp of language, the “whistling of a name,” or the simplicity or ingenuity of a pathological theory, that can long give it currency with mankind. The sole point is,
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  • H. J. Roberts
  • Medicine
    Journal of the American Geriatrics Society
  • 1964
TLDR
There is evidence for the combined role of diabetogenic hyperinsulinism and recurrent (idiopathic) edema in the genesis of multiple sclerosis in such patients, which affords the basis for rational treatment, but also for prophylaxis in the multiple sclerosis-prone person.
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There have been reported a number of cases of myoglobinuria, usually recurrent and unassociated with any traumatic or toxic event, and about one-third of these have been associated with muscular dystrophy.
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TLDR
Post-Gastro-enterostomy Dyspepsia may be the result of gastric discomforts associated with an inefficient or too efficient stoma and consequently feelings of fullness or empty feelings, but with an unsatisfactory loop bile may be absent in many specimens.
PSEUDOHYPOGLYCEMIC REACTIONS IN INSULIN‐TREATED DIABETICS: ETIOLOGY, LABORATORY AIDS AND THERAPY *
  • M. Fabrykant
  • Medicine
    Journal of the American Geriatrics Society
  • 1964
TLDR
The purpose of this paper is to stress the value of electroencephalographic studies in patients with pseudohypoglycemic reactions and unpredictable insulin reactions, and the importance of differential diagnosis.
VALUE OF CARISOPRODOL (SOMA) IN RELIEVING LEG CRAMPS
  • F. Stern
  • Medicine
    Journal of the American Geriatrics Society
  • 1963
TLDR
A double-blind, cross-over placebo controlled experimental design was employed to determine the effectiveness of carisoprodol in the treatment of 50 geriatric patients with intermittent claudication or nocturnal leg pains, in such a manner as to avoid any bias.
Myoglobinuria following diabetic acidosis with electromyographic evaluation.
TLDR
This case is of interest because of its association with the therapy of diabetic acidosis, because it is the first case in which electromyographic studies were done.
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TLDR
The study examined 14 more persons with a well-documented history of long-standing abuse and showed that signs of muscular affections were common and extensive necrosis of muscular fibers in several cases was demonstrated.
MUSCULAR DYSTROPHY. FEATURES OF OCULAR MYOPATHY, DISTAL MYOPATHY, AND MYOTONIC DYSTROPHY.
TLDR
The myopathy of myotonic dystrophy is different from most other dystrophies for three reasons: Limb weakness is primarily distal; cranial muscles are frequently affected; and myotonia is present.
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Excerpt A syndrome of unpleasant paresthesias, predominantly in the lower extremities, and the resultant voluntary, restless, twitching motions on the part of the sufferer to obtain relief, was pro...
STUDIES IN MYASTHENIA GRAVIS. PITUITARY-ADRENAL FUNCTION.
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