SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis

@article{Brdlein2011SPOC1I,
  title={SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis},
  author={Annegret B{\"o}rdlein and Harry Scherthan and Claudia Nelkenbrecher and Tina Molter and Michael R. Bösl and Christine S. Dippold and Kerstin Birke and Sarah Kinkley and Hannah Staege and Hans Will and Andreas Winterpacht},
  journal={Development},
  year={2011},
  volume={138},
  pages={e1907 - e1907}
}
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4 Citations
Background Citations
3
Methods Citations
1
Results Citations
1

4 Citations

Citation Type

Citation Type

PHF 13 is a molecular reader and transcriptional co-regulator of H 3 K 4 me 2 / 3
TLDR
It is argued that PHF13 is an H3K4me2/3 molecular reader and transcriptional co-regulator, affording it the ability to impact different chromatin processes.
Tuning the Orchestra: HCMV vs. Innate Immunity
TLDR
An up-to-date review of the mechanisms regulating the interplay between HCMV and innate immunity is provided, focusing on the various strategies of immune escape evolved by this virus to gain a fitness advantage.
Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication
TLDR
The functional characterization of the dual role of PHF13 during the HIV-1 replication cycle is revealed, revealing a surprising and intricate mechanism through which HIV- 1 might regulate the switch from integration to viral gene expression.
SPOC 1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response
TLDR
Findings provide the first evidence for a function of SPOC1 in DNA damage response (DDR) and repair, which involves its dose-dependent effects on DNA damage sensors, repair mediators and key regulators of chromatin.

References

SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis
TLDR
The data argue that SPOC1 is indispensable for stem cell differentiation in the testis and for sustained spermatogenesis.