SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis

  title={SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis},
  author={Annegret B{\"o}rdlein and Harry Scherthan and Claudia Nelkenbrecher and Tina Molter and Michael R. Bösl and Christine S. Dippold and Kerstin Birke and Sarah Kinkley and Hannah Staege and Hans Will and Andreas Winterpacht},
  journal={Journal of Cell Science},
  pages={3137 - 3148}
SPOC1 (PHF13) is a recently identified protein that has been shown to dynamically associate with somatic chromatin, to modulate chromatin compaction and to be important for proper cell division. Here, we report on the expression of SPOC1 in promyelocytic leukaemia zinc finger (PLZF)-positive undifferentiated spermatogonial stem cells (SSCs) of the mouse testis. To investigate further the biological function of SPOC1 in germ cells we generated Spoc1 mutant mice from a gene-trap embryonic stem… 

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