SPOC alert--when chromosomes get the wrong direction.


The asymmetrically dividing budding yeast relies upon the alignment of the mitotic spindle along the mother to daughter cell polarity axis for the fidelity of chromosome segregation during mitosis. In the case of spindle misalignment, a surveillance mechanism named the spindle position checkpoint (SPOC) prevents cells from exiting mitosis through the… (More)
DOI: 10.1016/j.yexcr.2012.03.031


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