SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing

  title={SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing},
  author={Fabrizia Carofiglio and Akiko Inagaki and Sandra S de Vries and Evelyne Wassenaar and Sam Schoenmakers and Christie Vermeulen and Wiggert A. van Cappellen and Esther Sleddens-Linkels and J. Anton Grootegoed and Hein Te Riele and Bernard de Massy and Willy M Baarends},
  booktitle={PLoS genetics},
In mammalian meiotic prophase, the initial steps in repair of SPO11-induced DNA double-strand breaks (DSBs) are required to obtain stable homologous chromosome pairing and synapsis. The X and Y chromosomes pair and synapse only in the short pseudo-autosomal regions. The rest of the chromatin of the sex chromosomes remain unsynapsed, contains persistent meiotic DSBs, and the whole so-called XY body undergoes meiotic sex chromosome inactivation (MSCI). A more general mechanism, named meiotic… CONTINUE READING
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