SPLASH: structural pattern localization analysis by sequential histograms

Abstract

MOTIVATION The discovery of sparse amino acid patterns that match repeatedly in a set of protein sequences is an important problem in computational biology. Statistically significant patterns, that is patterns that occur more frequently than expected, may identify regions that have been preserved by evolution and which may therefore play a key functional or… (More)
DOI: 10.1093/bioinformatics/16.4.341

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