SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.

@article{Sperrhacke2014SPINK9SM,
  title={SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.},
  author={Maria Sperrhacke and J. Fischer and Zhihong Wu and Sarah Kl{\"u}nder and R. Sedl{\'a}{\vc}ek and J. Schroeder and U. Meyer-Hoffert and K. Reiss},
  journal={The Journal of investigative dermatology},
  year={2014},
  volume={134 6},
  pages={
          1645-1654
        }
}
Serine protease inhibitors of the Kazal-type 9 (SPINK9) is a keratinocyte-derived cationic peptide that is found most abundantly in the upper layers of the palmar-plantar epidermis. In vitro, the peptide displays the capacity to inhibit specifically kallikrein-related peptidase 5 (KLK5). Here, we report that cells expressing SPINK9 secrete the peptide constitutively. Recombinant SPINK9 (rSPINK9) provoked transactivation of the EGFR in human keratinocytes, resulting in efficient downstream… Expand
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