SPINK1 protein expression and prostate cancer progression.

  title={SPINK1 protein expression and prostate cancer progression.},
  author={Richard John Flavin and Andreas Pettersson and Whitney K. Hendrickson and Michelangelo Fiorentino and Stephen Finn and Lauren M Kunz and Gregory L. Judson and Rosina T. Lis and Dyane Bailey and Christopher Fiore and Elizabeth J. Nuttall and Neil E. Martin and Edward C. Stack and Kathryn L. Penney and Jennifer R. Rider and Jennifer A. Sinnott and Christopher Sweeney and Howard D Sesso and Katja Fall and Edward L. Giovannucci and Philip W. Kantoff and Meir Jonathan Stampfer and Massimo Loda and Lorelei A. Mucci},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={20 18},
PURPOSE SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and prostate cancer-specific survival. EXPERIMENTAL DESIGN The study included 879 participants in the U.S. Physicians' Health Study and Health Professionals Follow-Up Study, diagnosed with prostate cancer (1983-2004) and treated by radical prostatectomy. Protein tumor expression of… CONTINUE READING


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