SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.


BACKGROUND & AIMS Gain-of-function trypsin mutations cause acute pancreatitis and chronic pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the prevalence of SPINK1 (PSTI) mutations in familial pancreatitis, idiopathic chronic pancreatitis, and controls. METHODS Genetic-linkage studies were performed in 5 familial… (More)


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