SPINAL: scalable protein interaction network alignment

@article{Alada2013SPINALSP,
  title={SPINAL: scalable protein interaction network alignment},
  author={Ahmet Emre Aladağ and Cesim Erten},
  journal={Bioinformatics},
  year={2013},
  volume={29 7},
  pages={917-24}
}
MOTIVATION Given protein-protein interaction (PPI) networks of a pair of species, a pairwise global alignment corresponds to a one-to-one mapping between their proteins. Based on the presupposition that such a mapping provides pairs of functionally orthologous proteins accurately, the results of the alignment may then be used in comparative systems biology problems such as function prediction/verification or construction of evolutionary relationships. RESULTS We show that the problem is NP… CONTINUE READING
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