SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.

@article{Goizet2009SPG15IT,
  title={SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.},
  author={Cyril Goizet and Amir Boukhris and David Malt{\^e}te and Lucie Guyant-Mar{\'e}chal and J{\'e}r{\'e}my Truchetto and Emeline Mundwiller and Sylvain Hanein and Philippe Jonveaux and Filip Roelens and Jos{\'e} F. Loureiro and Estelle Godet and Sylvie Forlani and Judith Melki and Michaela Auer-Grumbach and Jos{\'e} Carlos Couto Fernandez and P Martin-Hardy and Igor Sibon and Guilhem Sol{\'e} and Isabelle Orignac and Chokri Mhiri and Paula Coutinho and Alexandra Durr and Alexis Brice and Giovanni Stevanin},
  journal={Neurology},
  year={2009},
  volume={73 14},
  pages={1111-9}
}
OBJECTIVE Hereditary spastic paraplegias (HSPs) are very heterogeneous inherited neurodegenerative disorders. Our group recently identified ZFYVE26 as the gene responsible for one of the clinical and genetic entities, SPG15. Our aim was to describe its clinical and mutational spectra. METHODS We analyzed all exons of SPG15/ZFYVE26 gene by direct sequencing in a series of 60 non-SPG11 HSP subjects with associated mental or MRI abnormalities, including 30 isolated cases. The clinical data were… CONTINUE READING

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