SPG11 spastic paraplegia

  title={SPG11 spastic paraplegia},
  author={Dr. Mathieu Anheim and Clotilde Lagier-Tourenne and Giovanni Stevanin and Marie-Jos{\'e}e Fleury and Alexandra Durr and Izzie Namer and Paola Silvia Denora and Alexis Brice and J. L. Mandel and Michel Koenig and Christine Tranchant},
  journal={Journal of Neurology},
Autosomal recessive hereditary spastic paraplegia (AR HSP) with thin corpus callosum (TCC) is a rare neurodegenerative disorder often caused by mutations in the gene encoding for spatacsin at the SPG11 locus on chromosome 15q. The disease is characterized by progressive spastic paraparesis and mental retardation which occur during the first two decades of… CONTINUE READING