SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—IV. THE PHOTOLYSIS OF BENOXAPROFEN, AN ANTI‐INFLAMMATORY DRUG WITH PHOTOTOXIC PROPERTIES

@article{Reszka1983SPECTROSCOPICSO,
  title={SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—IV. THE PHOTOLYSIS OF BENOXAPROFEN, AN ANTI‐INFLAMMATORY DRUG WITH PHOTOTOXIC PROPERTIES},
  author={Krzysztof J. Reszka and Colin F. Chignell},
  journal={Photochemistry and Photobiology},
  year={1983},
  volume={38}
}
Abstract— Benoxaprofen [2‐(4‐chlorophenyl)‐α‐methyl‐5‐benzoxazole acetic acid] is an anti‐inflammatory drug that causes acute phototoxicity in many patients. Photolysis studies in organic solvents (ethanol, benzene, dimethylsulfoxide) showed that benoxaprofen underwent both Type I and Type II reactions. Irradiation of an anerobic solution of benoxaprofen in ethanol resulted in hydrogen abstraction from the solvent to yield hydroxyethyl and ethoxyl radicals. In the presence of oxygen, superoxide… Expand
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