SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.

@article{Laruelle1993SPECTIO,
  title={SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.},
  author={Marc Laruelle and Ronald M. Baldwin and Robert Malison and Yolanda Zea-Ponce and Sami S. Zoghbi and Mohammed S. Al-Tikriti and E H Sybirska and Ralf Zimmermann and Gary Wisniewski and John L. Neumeyer},
  journal={Synapse},
  year={1993},
  volume={13 4},
  pages={295-309}
}
Single photon emission computed tomography (SPECT) studies of regional kinetic uptake and pharmacological specificity of [123I]methyl 3 beta-(4-iodophenyl) tropane-2 beta-carboxylate ([123I]beta-CIT) were performed in nonhuman primates (n = 41). In control experiments, activity was concentrated in striatum and in hypothalamic/midbrain regions. Striatal uptake increased for 140-180 min and displayed stable levels thereafter. Striatal to cerebellar activity ratios were 7.3 +/- 0.9 (mean +/- SEM… CONTINUE READING

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