SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT. Binding kinetics in the human brain

@article{Brcke2005SPECTIO,
  title={SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT. Binding kinetics in the human brain},
  author={Doz. Dr. T. Br{\"u}cke and J. Kornhuber and P. Angelberger and S. Asenbaum and H. Frassine and I. Podreka},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={94},
  pages={137-146}
}
  • Doz. Dr. T. Brücke, J. Kornhuber, +3 authors I. Podreka
  • Published 2005
  • Psychology, Medicine
  • Journal of Neural Transmission / General Section JNT
  • Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative [123I]-2-β-carbomethoxy-3-β-(4-iodophenyl)-tropane ([123I]β-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamusmidbrain area. Here, we report on the regional kinetic uptake of [123I]β-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly… CONTINUE READING
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