SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder

@article{Krause2008SPECTAP,
  title={SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder},
  author={J. Krause},
  journal={Expert Review of Neurotherapeutics},
  year={2008},
  volume={8},
  pages={611 - 625}
}
  • J. Krause
  • Published 1 April 2008
  • Medicine
  • Expert Review of Neurotherapeutics
Abnormalities of frontostriatal circuits, which are modulated by dopamine, have been found by brain imaging studies in patients with attention-deficit/hyperactivity disorder (ADHD). With special radiolabeled ligands selective imaging of the dopamine transporter (DAT), which has a key function in dopamine metabolism, can be performed by SPECT and PET. Most of the studies showed a higher DAT availability in untreated patients with ADHD compared with controls. The relationship between DAT… Expand
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Attention Deficit/Hyperactivity Disorder: Is There a Correlation Between Dopamine Transporter Density and Cerebral Blood Flow?
TLDR
It is postulated that individuals with ADHD, with a higher DAT density in the basal ganglia, will have lower perfusion in the fronto-striatal-cerebellar networks. Expand
Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: A preliminary study
TLDR
Findings suggest that peripheral DAT1 promoter methylation may be predictive of striatal DAT availability in adults with ADHD and controls. Expand
Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
TLDR
The preliminary findings suggest that low DAT occupancy is not the reason why ADHD patients with cocaine dependence do not benefit from MPH treatment and that higher dosages of MPH in these patients are probably not the solution and that medications directed at other pharmacological targets should be considered in these comorbid ADHD patients. Expand
The dopamine transporter haplotype and reward-related striatal responses in adult ADHD
TLDR
The importance of the DAT1 haplotype as a risk factor for adult ADHD was again demonstrated in this study, and the mechanism by which this gene increases disease risk remains largely unknown. Expand
The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder
TLDR
It is anticipated that the application of refined and novel positron emission tomography methodology will help to disentangle the overlapping and dissociable contributions of DA and noradrenaline in the prefrontal cortex, thereby aiding the understanding of ADHD and facilitating new treatments. Expand
Impulsivity is related to striatal dopamine transporter availability in healthy males
TLDR
It is found that greater dopamine transporter availability was associated with higher BIS impulsivity but not with ADHD-related traits, suggesting that individual differences in the dopamine system may be a neural correlate of trait impulsivity in healthy individuals. Expand
Striatal presynaptic dopamine in schizophrenia, Part I: meta-analysis of dopamine active transporter (DAT) density.
TLDR
The data suggest that altered integrity of striatal dopamine synapses is not critical for the emergence of schizophrenia or its treatment, and should be useful in further refining dopaminergic hypotheses of schizophrenia. Expand
Human Brain Imaging of Dopamine Transporters
Abstract The dopamine transporter (DAT) is a transmembrane protein that is responsible for the reuptake of dopamine (DA) from the synaptic cleft and for the termination of dopaminergic transmission.… Expand
Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks
TLDR
It is shown that DMN suppression is likely linked to DAT1 and to severity of inattention in ADHD, and may be a target of DAT2 effects, and lie on the path between the gene and inatt attention in ADHD. Expand
Recent Advances in Imaging of Dopaminergic Neurons for Evaluation of Neuropsychiatric Disorders
TLDR
This review will concentrate on the radiotracers that have been developed for imaging dopaminergic neurons, describe the clinical aspects in the assessment of neuropsychiatric disorders, and suggest future directions in the diagnosis and management of such disorders. Expand
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References

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TLDR
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TLDR
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