SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder

  title={SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder},
  author={J. Krause},
  journal={Expert Review of Neurotherapeutics},
  pages={611 - 625}
  • J. Krause
  • Published 1 April 2008
  • Psychology, Medicine
  • Expert Review of Neurotherapeutics
Abnormalities of frontostriatal circuits, which are modulated by dopamine, have been found by brain imaging studies in patients with attention-deficit/hyperactivity disorder (ADHD). With special radiolabeled ligands selective imaging of the dopamine transporter (DAT), which has a key function in dopamine metabolism, can be performed by SPECT and PET. Most of the studies showed a higher DAT availability in untreated patients with ADHD compared with controls. The relationship between DAT… 

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Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention‐deficit/hyperactivity disorder

  • Ariel B. BrownJ. Biederman L. Seidman
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype, which may contribute to heterogeneity of brain alterations found within ADHD samples.



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