SPECT analysis of cardiac perfusion changes after whole-breast/chest wall radiation therapy with or without active breathing coordinator: results of a randomized phase 3 trial.

@article{Zellars2014SPECTAO,
  title={SPECT analysis of cardiac perfusion changes after whole-breast/chest wall radiation therapy with or without active breathing coordinator: results of a randomized phase 3 trial.},
  author={Richard Zellars and Paco E. Bravo and Erik Tryggestad and Kari Hopfer and Lee Myers and A. Tahari and Fariba Asrari and Harvey A. Ziessman and Elizabeth Garrett-Mayer},
  journal={International journal of radiation oncology, biology, physics},
  year={2014},
  volume={88 4},
  pages={778-85}
}
PURPOSE Cardiac muscle perfusion, as determined by single-photon emission computed tomography (SPECT), decreases after breast and/or chest wall (BCW) irradiation. The active breathing coordinator (ABC) enables radiation delivery when the BCW is farther from the heart, thereby decreasing cardiac exposure. We hypothesized that ABC would prevent radiation-induced cardiac toxicity and conducted a randomized controlled trial evaluating myocardial perfusion changes after radiation for left-sided… CONTINUE READING
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