SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection.

Abstract

UNLABELLED The present study evaluated the role of SPECT/CT as an adjunct to (67)Ga (GS) or (111)In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection. METHODS Eighty-two patients (56 male and 26 female; mean age, 62 y) assessed for known or suspected infectious processes underwent 88 SPECT/CT studies. Forty-seven patients underwent GS SPECT/CT (13 with fever of unknown origin, 21 with suspected osteomyelitis, and 13 with suspected soft-tissue infection), and 35 patients underwent WBC SPECT/CT (24 with suspected vascular graft infection, and 11 with suspected osteomyelitis). Ninety-eight suggestive sites were identified (52 on GS and 46 on WBC). Additional information provided by SPECT/CT for diagnosis or localization of infection, as compared with planar and SPECT scintigraphy, was recorded. The SPECT/CT contribution was analyzed on a patient and site basis and was compared for the 2 tracers and clinical indications. RESULTS SPECT/CT provided additional information for infection diagnosis and localization in 39 (48%) of 82 patients and in 47 (48%) of 98 sites. SPECT/CT defined the extent of infection in 35 patients (43%) in 43 sites (44%) and excluded infection in 4 suggestive sites defined as physiologic bowel uptake on GS. SPECT/CT was incorrect in 2 suggestive sites (1 GS and 1 WBC). The contribution of SPECT/CT was significantly higher for WBC than for GS (P < 0.05)--in 63% versus 36% of patients, respectively, and in 61% versus 36% of sites, respectively. CONCLUSION SPECT/CT made an incremental contribution to GS and WBC in 48% of patients with suspected infections, by improving diagnosis, localization, and definition of extent of disease. SPECT/CT has an important role mainly with highly specific, low-background infection-seeking tracers such as WBC.

6 Figures and Tables

050100150'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

380 Citations

Semantic Scholar estimates that this publication has 380 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{BarShalom2006SPECTCTU6, title={SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection.}, author={Rachel Bar-Shalom and Nikolay Yefremov and Luda Guralnik and Zohar Keidar and Ahuva Engel and Samy S. Nitecki and Ora Israel}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={2006}, volume={47 4}, pages={587-94} }