SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.

  title={SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.},
  author={Daniel B. Constam and Elisabeth J Robertson},
  journal={Genes & development},
  volume={14 9},
In vertebrates, specification of anteroposterior (A/P) and left-right (L/R) axes depends on TGFbeta-related signals, including Nodal, Lefty, and BMPs. Endoproteolytic maturation of these proteins is probably mediated by the proprotein convertase SPC1/Furin. In addition, precursor processing may be regulated by related activities such as SPC4 (also known as PACE4). Here, we show that a proportion of embryos lacking SPC4 develop situs ambiguus combined with left pulmonary isomerism or complex… CONTINUE READING

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