Corpus ID: 2383168

SPATA 2 promotes CYLD activity and regulates TNF-induced NF-j B signaling and cell death

@inproceedings{Schlicher2016SPATA2P,
  title={SPATA 2 promotes CYLD activity and regulates TNF-induced NF-j B signaling and cell death},
  author={Lisa Schlicher and Manuela Wissler and Florian Preiss and Prisca Brauns-Schubert and Celia Jakob and Ver{\'o}nica I. Dumit and Christoph Borner and J{\"o}rn Dengjel and Ulrich Maurer},
  year={2016}
}
  • Lisa Schlicher, Manuela Wissler, +6 authors Ulrich Maurer
  • Published 2016
  • K63and Met1-linked ubiquitylation are crucial posttranslational modifications for TNF receptor signaling. These non-degradative ubiquitylations are counteracted by deubiquitinases (DUBs), such as the enzyme CYLD, resulting in an appropriate signal strength, but the regulation of this process remains incompletely understood. Here, we describe an interaction partner of CYLD, SPATA2, which we identified by a mass spectrometry screen. We find that SPATA2 interacts via its PUB domain with CYLD… CONTINUE READING

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