SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

@inproceedings{Zhao2018SPARCL1SO,
  title={SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex},
  author={S Zhao and Yiling Jiang and N Xu and Quan Li and Qiaoxia Zhang and Lijun Wang and Ji Li and Y Wang and Yumeng Zhang and S-H Jiang and Y-j Wang and Y-J Huang and Xin-Xin Zhang and G Tian and Chengfei Zhang and Y-Y Lv and Miao Dai and Feng Liu and Ruiyan Zhang and Dong Zhou and Z Zhang},
  booktitle={Oncogene},
  year={2018}
}
Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore, identification of novel targets remains extremely important to prevent metastasis and treat OS. In this report, we show that SPARCL1 is downregulated in OS by epigenetic methylation of promoter DNA. In vitro and in vivo experiments revealed that SPARCL1 inhibits OS metastasis. We further demonstrated that SPARCL1-activated WNT/β-catenin signaling by physical interaction with various frizzled receptors… CONTINUE READING
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