SPARC ameliorates ovarian cancer-associated inflammation.

  title={SPARC ameliorates ovarian cancer-associated inflammation.},
  author={Neveen A Said and Ahmed A. Elmarakby and John D Imig and David Fulton and Kouros Motamed},
  volume={10 10},
We have recently identified that the role of secreted protein acidic and rich in cysteine (SPARC) in amelioration of peritoneal ovarian carcinomatosis is mediated, at least in part, through mesothelial cell/lysophosphatidic acid-induced inflammatory response in ovarian cancer cells. The aim of this study was to elucidate the molecular mechanisms of the interactions between tumor cells and the cellular components of the ovarian cancer peritoneal microenvironment, specifically, mesothelial cells… CONTINUE READING


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