SPARC Controls Melanoma Cell Plasticity through Rac1

Abstract

Cell transition to a more aggressive mesenchymal-like phenotype is a hallmark of cancer progression that involves different steps and requires tightly regulated cell plasticity. SPARC (Secreted Protein Acidic and Rich in Cysteine) is a matricellular protein that promotes this transition in various malignant cell types, including melanoma cells. We found… (More)
DOI: 10.1371/journal.pone.0134714

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