SP7 Inhibits Osteoblast Differentiation at a Late Stage in Mice

  title={SP7 Inhibits Osteoblast Differentiation at a Late Stage in Mice},
  author={Carolina Andrea Yoshida and Hisato Komori and Zenjiro Maruyama and Toshihiro Miyazaki and Keishi Kawasaki and Tatsuya Furuichi and Ryo Fukuyama and Masako Mori and Kei Yamana and Kouhei Nakamura and Wenguang Liu and Satoru Toyosawa and Takeshi Moriishi and Hiroshi Kawaguchi and Kenji Takada and Toshihisa Komori},
  booktitle={PloS one},
RUNX2 and SP7 are essential transcription factors for osteoblast differentiation at an early stage. Although RUNX2 inhibits osteoblast differentiation at a late stage, the function of SP7 at the late stage of osteoblast differentiation is not fully elucidated. Thus, we pursued the function of SP7 in osteoblast differentiation. RUNX2 induced Sp7 expression in Runx2(-/-) calvarial cells. Adenoviral transfer of sh-Sp7 into primary osteoblasts reduced the expression of Alpl, Col1a1, and Bglap2 and… CONTINUE READING
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Publications referenced by this paper.
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Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 2 Excerpts

Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2009
View 3 Excerpts

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