SP100B, a repressor of gene expression preferentially binds to DNA with unmethylated CpGs.

@article{Isaac2006SP100BAR,
  title={SP100B, a repressor of gene expression preferentially binds to DNA with unmethylated CpGs.},
  author={Anne Isaac and Kent W Wilcox and Jerry L Taylor},
  journal={Journal of cellular biochemistry},
  year={2006},
  volume={98 5},
  pages={1106-22}
}
SP100A and SP100B are mammalian nuclear proteins encoded by alternatively-spliced transcripts from the SP100 gene. The N-terminal portion of SP100B (aa 1-476) is identical to SP100A and contains an HP1 interaction domain. The C-terminal portion of SP100B (aa 477-688) contains an HMG2 interaction domain and a SAND domain. The SAND domain is a DNA-binding domain identified in several nuclear proteins involved in transcriptional regulation. We have previously reported that SP100B represses… CONTINUE READING

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