SP-A enhances uptake of bacillus Calmette-Guérin by macrophages through a specific SP-A receptor.

@article{Weikert1997SPAEU,
  title={SP-A enhances uptake of bacillus Calmette-Gu{\'e}rin by macrophages through a specific SP-A receptor.},
  author={Lars Weikert and Kaye Edwards and Zissis C Chroneos and Clyde Hager and Larry Hoffman and Virginia L. Shepherd},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 1},
  pages={
          L989-95
        }
}
Surfactant-associated protein A (SP-A) is a C-type lectin that is involved in surfactant metabolism as well as host defense functions in the lung. We have recently identified a receptor on macrophages [specific 210-kDa SP-A receptor (SPR210)] that binds SP-A. In the current study we have investigated the role of SP-A in mediating uptake of bacillus Calmette-Guérin (BCG) by rat macrophages and human monocytes and have examined the role of the macrophage SPR210 in this process. 125I-labeled SP-A… CONTINUE READING

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