SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer.

@article{Wang2013SOX9RL,
  title={SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer.},
  author={Hong-yun Wang and Lingfeng He and Fen Ma and Meredith M. Regan and Steven P. Balk and Andrea L. Richardson and Xin Yuan},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 9},
  pages={6478-87}
}
Gene expression profiling has identified breast cancer (BCa) subtypes, including an aggressive basal-like (BL) subtype. The molecular signals underlying the behavior observed in BL-BCa group are largely unknown, although recent results indicate a prevalent increase in Wnt/β-catenin activity. Our immunohistochemistry study confirmed that SOX9, one of the BL-BCa signature genes, was expressed by most BL-BCa, and its expression correlated with indicators of poor prognosis. Importantly, BCa gene… CONTINUE READING
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