SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells.

@article{Wang2007SOX9IE,
  title={SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells.},
  author={Hong-yun Wang and Nicole C. McKnight and Tao Zhang and Michael L. Lu and Steven P. Balk and Xin Yuan},
  journal={Cancer research},
  year={2007},
  volume={67 2},
  pages={528-36}
}
SOX9 is a member of the SOX [Sry-related high-mobility group (HMG) box] family of HMG DNA-binding domain transcription factors and is required for the development and differentiation of multiple cell lineages. This report shows that basal epithelial cells express SOX9 in normal prostate, with no detectable expression in luminal epithelial cells. In contrast, SOX9 is expressed in primary prostate cancers in vivo, at a higher frequency in recurrent prostate cancer and in prostate cancer cell… CONTINUE READING

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