SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

@article{Blache2004SOX9IA,
  title={SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes},
  author={Philippe Blache and Marc van de Wetering and Isabelle Duluc and Claire Domon and Philippe Berta and Jean-No{\"e}l Freund and Hans Clevers and Philippe Jay},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={166},
  pages={37 - 47}
}
TCF and SOX proteins belong to the high mobility group box transcription factor family. Whereas TCFs, the transcriptional effectors of the Wnt pathway, have been widely implicated in the development, homeostasis and disease of the intestine epithelium, little is known about the function of the SOX proteins in this tissue. Here, we identified SOX9 in a SOX expression screening in the mouse fetal intestine. We report that the SOX9 protein is expressed in the intestinal epithelium in a pattern… CONTINUE READING
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SOX9 directly regulates the type-ll collagen gene

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