SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus.

@article{Zhang2005SOX7IA,
  title={SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus.},
  author={Chi Zhang and Tamara Basta and Shana R Fawcett and Michael W Klymkowsky},
  journal={Developmental biology},
  year={2005},
  volume={278 2},
  pages={526-41}
}
In zebrafish, the divergent F-type SOX casanova acts downstream of Nodal signaling to specify endoderm. While no casanova orthologs have been identified in tetrapods, the F-type SOX, SOX7, is supplied maternally in Xenopus (Fawcett and Klymkowsky, 2004. GER 4, 29). Subsequent RT-PCR and section-based in situ hybridization analyses indicate that SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo. Overexpression and maternal depletion studies reveal that the T-box… CONTINUE READING

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