SOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes

@article{Lai2008SOX5CT,
  title={SOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes},
  author={Tina Lai and Denis Jabaudon and Bradley J. Molyneaux and Eiman Azim and Paola Arlotta and Jo{\~a}o R. L. Menezes and Jeffrey D Macklis},
  journal={Neuron},
  year={2008},
  volume={57}
}
The molecular mechanisms controlling the development of distinct subtypes of neocortical projection neurons, and CNS neuronal diversity more broadly, are only now emerging. We report that the transcription factor SOX5 controls the sequential generation of distinct corticofugal neuron subtypes by preventing premature emergence of normally later-born corticofugal neurons. SOX5 loss-of-function causes striking overlap of the identities of the three principal sequentially born corticofugal neuron… CONTINUE READING
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