SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

@inproceedings{Santini2014SOX2RS,
  title={SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells},
  author={Rafael Santini and Silvia Pietrobono and S Pandolfi and Valentina Montagnani and Massimo D'Amico and Junia Yara Penachioni and Maria Cristina Vinci and Lorenzo Borgognoni and Barbara Stecca},
  booktitle={Oncogene},
  year={2014}
}
Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHOG-GLI (HH-GLI) signaling is required for melanoma growth and for survival and expansion of melanoma-initiating cells (MICs). Recent reports indicate that HH-GLI signaling regulates a set of genes typically expressed in embryonic stem cells, including SOX2 (sex-determining region Y (SRY… CONTINUE READING
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