SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

@inproceedings{Liu2017SOX2RM,
  title={SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis},
  author={Kuancan Liu and Fuan Xie and Anding Gao and Rui Zhang and Long Zhang and Zhangwu Xiao and Qiong Hu and Weifeng Huang and Qiaojia Huang and Baoshun Lin and Jian Zhu and Haikun Wang and Jianwen Que and Xiao-peng Lan},
  booktitle={Molecular Cancer},
  year={2017}
}
High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood. In this study we investigate the role of SOX2 in breast cancer metastasis using multiple in vitro and in vivo assays including cell culture, shRNA-mediated knockdown, wound healing, colony formation, transwell chamber, xenograft and tail vein injection. Moreover, western blot, immunostaining, microarray and real-time PCR were used to… CONTINUE READING

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