SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs

@inproceedings{Hagey2018SOX2RC,
  title={SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs},
  author={Daniel W. Hagey and Susanne Klum and Idha Kurtsdotter and C{\'e}cile Zaouter and Danijal Topcic and Olov Andersson and Maria Bergsland and Jonas Muhr},
  booktitle={PLoS genetics},
  year={2018}
}
Stem cells are defined by their capacities to self-renew and generate progeny of multiple lineages. The transcription factor SOX2 has key roles in the regulation of stem cell characteristics, but whether SOX2 achieves these functions through similar mechanisms in distinct stem cell populations is not known. To address this question, we performed RNA-seq and SOX2 ChIP-seq on embryonic mouse cortex, spinal cord, stomach and lung/esophagus. We demonstrate that, although SOX2 binds a similar motif… CONTINUE READING
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