SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

@article{Mu2017SOX2PL,
  title={SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer},
  author={Ping Mu and Zeda Zhang and Matteo Benelli and Wouter R. Karthaus and Elizabeth Hoover and Chi-Chao Chen and John Wongvipat and Sheng-Yu Ku and Dong Gao and Zhen Cao and Neel Shah and Elizabeth J. Adams and Wassim M. Abida and P. A. Watson and Davide Prandi and Chun-Hao Huang and Elisa de Stanchina and Scott W Lowe and Leigh Ellis and Himisha Beltran and Mark A. Rubin and David W Goodrich and Francesca Demichelis and Charles L Sawyers},
  journal={Science},
  year={2017},
  volume={355},
  pages={84-88}
}
Some cancers evade targeted therapies through a mechanism known as lineage plasticity, whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the drug target. We use in vitro and in vivo human prostate cancer models to show that these tumors can develop resistance to the antiandrogen drug enzalutamide by a phenotypic shift from androgen receptor (AR)–dependent luminal epithelial cells to AR-independent basal-like cells. This lineage… CONTINUE READING
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